Beyond Weight Loss: Pallas Health’s NAD+ and Longevity Programs, Reviewed

Most people find Pallas Health because they typed “compounded semaglutide” into a search bar. What fewer notice is the second half of the menu — the anti-aging column, where NAD+ and sermorelin sit next to the weight-loss drugs like they belong to the same conversation. They don’t, quite. This is a different kind of purchase: less “lose 30 pounds,” more “feel less wrecked at 4pm and maybe age a little slower.” I spent time on the longevity side of Pallas specifically, because it deserves its own honest look rather than a footnote under a GLP-1 review.

What Pallas Health’s longevity programs actually are

Two products anchor the anti-aging side. NAD+ comes as either a daily nasal spray or a weekly injection, pitched for everyday energy and healthy-aging routines. Sermorelin is a weekly injection — a synthetic analog of growth-hormone-releasing hormone, 29 amino acids long, that nudges your own pituitary to release more growth hormone rather than injecting the hormone itself. Both are clinician-prescribed, compounded in U.S. pharmacies, ship in about a week, and are FSA/HSA eligible. Neither is a supplement you can grab off a shelf, and that distinction is the whole point of going through a telehealth clinician.

Say the important part plainly: NAD+ and compounded sermorelin are not FDA-approved products. The FDA hasn’t evaluated them for safety, effectiveness, or quality the way it has an approved drug. They’re legal as prescribed, compounded treatments, and whether either is appropriate for you is a licensed prescriber’s decision. Pallas is upfront that a clinician can decline to prescribe — nothing ships until one signs off.

A quick primer, because the marketing rarely bothers. NAD+ is a coenzyme every cell in your body uses to make energy and run repair processes, and its levels fall as you get older — that decline is the biological hook the whole category hangs on. The theory is that topping it back up supports energy and cellular maintenance. Sermorelin works a floor below that, on the hormonal signaling side. Both are plausible mechanisms. Plausible isn’t the same as proven, which is a thread I’ll pull harder in a minute.

Pallas Health NAD+ and sermorelin pricing, side by side

Here’s a spot where Pallas is more transparent than I expected going in. The pricing is published, all-in, with no separate membership fee — the plan, the provider care, and the ongoing check-ins are folded into one number.

Program	Format	First month	Ongoing
NAD+ (spray)	Daily nasal spray	~$79	~$189–$199/mo avg
NAD+ (injection)	Weekly injection	~$89	~$189–$199/mo avg
Sermorelin	Weekly injection	$89	$597 / 12 weeks (~$199/mo)

The first-month teaser is real but temporary — the honest number to plan around is roughly $199 a month once you’re past the intro. Sermorelin bills in a 12-week block ($597), which quietly locks you into a quarter at a time and auto-renews unless you cancel. That’s not hidden, but it’s the kind of thing you skim past when a $89 headline is doing the talking.

The honest part: where the evidence gets thin

This is where I have to slow down. Pallas’s pricing is clearer than its evidence base, and that’s the real catch on the longevity side — not the cost. NAD+ as an anti-aging intervention rests largely on animal studies and small human trials; the “reverse aging” framing you see across the whole industry runs well ahead of what’s actually been proven in people. Sermorelin has a longer clinical history as a growth-hormone stimulant, but the specific promise of longevity and body-recomposition in healthy adults is still more hopeful than settled.

None of that makes Pallas dishonest — they’re selling clinician-supervised access to real compounded medications, which is legitimate. It means you’re buying into a category where the marketing is confident and the science is still catching up. If you go in expecting a measurable, guaranteed anti-aging result, you’ll likely be disappointed. If you go in curious, monitored by a clinician, and clear-eyed about the gap, that’s a more reasonable footing.

Who the NAD+ and sermorelin route suits

Context helps set expectations. GLP-1 drugs took off because obesity affects roughly 42% of U.S. adults per NIH figures — a concrete problem with hard outcome data behind the medication. Longevity peptides are a different animal: the “problem” is aging itself, which is universal and slippery to measure. So the people who get the most from Pallas’s anti-aging line tend to already be doing the boring fundamentals — sleep, resistance training, protein — and want a clinician-guided experiment on top, not a shortcut instead.

It suits less well anyone hoping a weekly injection replaces the fundamentals, or anyone on a tight budget who’d feel the ~$199 monthly pinch without a clear payoff. Roughly $2,400 a year is real money for a benefit you can’t easily see on a scale. Go in treating it as an informed trial with a provider watching, and ask what “success” would even look like before you start.

Frequently asked questions

Is Pallas Health’s NAD+ the same as an IV drip at a wellness clinic?

No. Pallas delivers NAD+ as an at-home daily nasal spray or weekly injection rather than an in-clinic IV. It’s a clinician-prescribed compounded medication you self-administer, which is why it’s cheaper and more convenient than drip appointments — but it’s still not an FDA-approved product.

Does sermorelin actually work like HGH?

Not directly. Sermorelin signals your own pituitary to release more growth hormone, rather than adding synthetic HGH to your body. Supporters argue that’s a gentler, more natural mechanism, but the longevity and body-composition claims in healthy adults still outpace the hard evidence.

What does the Pallas longevity plan actually cost per year?

After the discounted first month, expect roughly $199 a month, or about $2,400 a year, for either NAD+ or sermorelin. Sermorelin bills as $597 every 12 weeks and auto-renews, so budget for the quarterly charge, not just the intro price.

Can I combine Pallas’s longevity programs with its GLP-1 weight-loss plan?

Potentially, since Pallas offers both under one account, but that’s strictly a clinical decision. Stacking compounded treatments raises the questions your prescriber needs to weigh — interactions, side effects, and whether you actually need all of them. Ask before assuming you can add them together.